OH. This product is sold commercially under a variety of names: Butyl Cellosolve ( Union Carbide ), Butyl Oxitol ( Shell Chemical ), Dowanol EB ( Dow Chemical ), Ektasolve EB ( Eastman Chemical ), Glycol Ether EB ( Oxy Petrochemicals ), 2-Butoxyethanol, and Ethylene Glycol Monobutyl Ether. Department of Health and Human Services. [14], In the petroleum industry, 2-butoxyethanol is a component of fracturing fluids, drilling stabilizers, and oil slick dispersants for both water-based and oil-based hydraulic fracturing[10][clarification needed] When liquid is pumped into the well, the fracturing fluids are pumped under extreme pressure, so 2-butoxyethanol is used to stabilize them by lowering the surface tension. It is liable to form peroxides on exposure to air and light. [27], Environment and Health Canada recommended that 2-butoxyethanol be added to Schedule 1 of the Canadian Environmental Protection Act, 1999 (CEPA). [13], 2-Butoxyethanol has a low acute toxicity, with LD50 of 2.5 g/kg in rats. 705 General Washington Avenue | Suite 703 | The glycol ethers aid in soil penetration and suspension for cleaners and in the case of coatings, pigment suspension and leveling. It is also approved by the U.S. FDA to be used as direct and indirect food additives, which include antimicrobial agents, defoamers, stabilizers, and adhesives. 10.4. 10.3. Workers may be harmed from exposure to 2-butoxyethanol. C. 4. This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. Ethylene glycol is a “toxic alcohol”, meaning that although chemically it is similar to ethanol (the active component of alcoholic beverages), it is much more poisonous if Glycol Ether EB is a solvent used in a wide range of industries. 2-butoxyethanol (or ethylene glycol monobutyl ether) and other glycol ethers. Ethylene Glycol Monoethyl Ether . Automotive antifreeze, containing 95% ethylene glycol, is the most common source of EG poisoning. Molecular Weight 146.23 . Blood or urine concentrations of 2-butoxyethanol or the metabolite 2-butoxyacetic acid may be measured using chromatographic techniques. Interactive image; ChEBI: CHEBI:64275 ChEMBL: ChEMBL1229846 ChemSpider: 13848467 ECHA InfoCard: 100.004.173: PubChem CID. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." Medical Conditions Aggravated By Exposure: Due to its defatting properties, isopropyl alcohol may aggravate an existing skin condition. low . Web. The course of the disinfection (at 30°C.) NTP, ACGIH, or OSHA. For more than 60 years, glycol ethers have been used as key ingredients in the production of cleaners, degreasers, water-based coatings, and solvent based coating systems. Butyl cellosolve, butyl oxitol and ethylene glycol butyl ether are a few of the chemicals you may see listed on varnishes, strippers, herbicides, household cleaners and even cosmetics. Synonyms Ethylene Glycol Monobutyl Ether, Butyl Cellosolve* 8 ETHYLENE GLYCOL ETHERS, NTP TOXICITY REPORT NUMBER 26 Glycol alkyl ethers represent a class of high-production-volume chemicals with widespread industrial applications as solvents and chemical intermediates. 2-Butoxyethanol is commonly obtained through two processes; the ethoxylation reaction of butanol and ethylene oxide in the presence of a catalyst: or the etherification of butanol with 2-chloroethanol. Germicidally effective, d-limonene-containing aqueous pump-spray compositions are rendered clear and stable by monoethers of certain aliphatic glycols which also enhance soil and stain removal from hard surfaces. Learn why Butyl aka Ethylene Glycol Monobutyl Ether EGBE has been used as key ingredients in the production of cleaners, degreasers and coatings for years. [9] Laboratory tests by the U. S. National Toxicology Program have shown that only sustained exposure to high concentrations (100-500 ppm) of 2-butoxyethanol can cause adrenal tumors in animals. It is a known respiratory irritant[3] and can be acutely toxic but animal studies did not find it to be mutagenic, and no studies suggest it is a human carcinogen. CleanItSupply.com | 2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH (Bu = CH3CH2CH2CH2). disinfectants, and chemical reagents. [7] It is often produced industrially by combining ethylene glycol and butyraldehyde in a Parr reactor with palladium on carbon. [33] After it was deleted from a UN list of substances requiring special toxicity labeling in 1994, and a subsequent petition by the American Chemistry Council, 2-butoxyethanol was removed from the U.S. Environmental Protection Agency's list of hazardous air pollutants in 2004. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). Atmospheric Chemistry and Physics, 11, 7209. Which products contain ethylene glycol? [22] It has not been identified as a major environmental contaminant, nor is it known to bio-accumulate. coli and several concentrations of ethylene glycol and the following ethers: monomethyl, monoethyl, monopropyl, monobutyl and monohexyl has been investigated. 2010. Butyl CELLOSOLVE™ glycol ether is a fast-evaporating glycol ether with an excellent balance of hydrophilic and hydrophobic character; excellent active solvency and coupling properties. 2. [8], In 2006, the European production of butyl glycol ethers amounted to 181 kilotons, of which approximately 50% (90 kt/a) was 2-Butoxyethanol. The range of exposure for the two species was between 70 mg/kg body weight per day to 1300 mg/kg body weight per day. WIPE, DISINFECTANT CAVIWIPES XLG SNGL 12X10 (50/BX. For quantities of 55 Gallons, we will contact you with a shipping quote prior to processing your order. Ethylene glycol monobutyl ether: The US National Toxicology Program (NTP) conducted a 2-year inhalation chronic toxicity and carcinogenicity study with ethylene glycol monobutyl ether in rats and mice. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)", "U.S. EPA's IRIS assessment of 2-Butoxyethanol: the relationship of noncancer to cancer effects", "Chemical Sampling Information | 2-Butoxyethanol", "ATSDR - ToxFAQs™: 2-Butoxyethanol and 2-Butoxyethanol Acetate", http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf, http://www.atsdr.cdc.gov/toxprofiles/tp118.pdf, "Current Use Patterns in Canada, Toxicology Profiles of Alternatives, and the Feasibility of Performing an Exposure Assessment Survey", "Regulations Amending the 2-Butoxyethanol Regulations", "California Code of Regulations, Title 8, Section 339. Ethylene glycol monohexyl ether BioXtra, ≥99.0% (GC) Synonym: 2-(Hexyloxy)ethanol, C 6 E 1, Hexylglycol CAS Number 112-25-4. The course of ethylene glycol toxicity is classically divided into three broad overlapping categories of adverse health effects. EGBE is made by reacting ethylene oxide with monobutyl ether. A significant increase in the incidence of liver hemangiosarcomas was seen in male mice and forestomach tumors in female mice. Linear Formula CH 3 (CH 2) 5 OCH 2 CH 2 OH . Beilstein/REAXYS Number 1734691 . It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. Ethylene Glycol Monobutyl Ether 111-76-2 50ppm 25ppm 3.0 Other Ingredients Water and other inert ingredients 3 - PHYSICAL AND CHEMICAL PROPERTIES Boiling Point: 191 ºF Specific Gravity (H 20 = 1): 0.972 at 25 C Vapor Pressure (mm Hg): Similar to water Vapor Density (AIR = 1): Similar to water Freezing/Melting Point: -10 C Sklar® Surface Disinfectant 24 oz. [26], Harmful effects have been observed in nonhuman mammals exposed to high levels of 2-butoxyethanol. This propylene type of glycol ether is relatively new and is slowly finding its way into cleaning formulations. Hullar, T.; Anastasio, C. Yields of hydrogen peroxide from the reaction of hydroxyl radical with organic compounds in solution and ice. Glycol ethers are selected for specific purposes, such as solubility, inflammability, and volatility. Despite reassuring results from toxicological tests involving EGBE, studies of other similar sounding ethylene glycol ethers have sparked scientific inquiry, media coverage, and regulatory attention. [28], When exposed to 2-butoxyethanol in drinking water, both F344/N rats and B63F1 mice showed negative effects. [21], 2-Butoxyethanol can be disposed of by incineration. PubChem Substance ID 329747820. NACRES NA.25 Although there are alternatives to EGBE for individual applications, there is no across-the-board replacement. Additionally, 2-butoxyethanol was associated with a significant decrease in maternal body weight, uterine weight, and number of total implants. Both the combination product and the sodium hypochlorite detergent had decreased efficacy when the ethylene glycol product was added. Ethylene glycol is a “toxic alcohol”, meaning that although chemically it is similar to ethanol (the active component of alcoholic beverages), it is much more poisonous if consumed. For quantities of 55 Gallons, we will contact you with a shipping quote prior to processing your order. US4540505A US06/296,759 US29675981A US4540505A US 4540505 A US4540505 A US 4540505A US 29675981 A US29675981 A US 29675981A US 4540505 A US4540505 A US 4540505A Authority US United States Prior art keywords percent composition alkyl glycol limonene Prior art date 1981-05-22 Legal status (The legal status is an assumption and is not a legal conclusion. propellant is a simple asphyxiant. [10] Because of its surfactant properties, it is a major constituent (30–60% w/w) in the oil spill dispersant Corexit 9527,[16] which was widely used in the aftermath of the 2010 Deepwater Horizon oil spill. DIETHYLENE GLYCOL MONOMETHYL ETHER is a ether-alcohol derivative. [10] As a surfactant, 2-butoxyethanol adsorbs at the oil-water interface of the fracture. [24][25] 2-Butoxyethanol and its metabolites fall to undetectable levels in urine after about 30 hours in human males. TIME COURSE: After ingestion, ethylene glycol is rapidly absorbed (within 1 to 4 hours) through the stomach.Following absorption, 80% or more of ethylene glycol is chemically converted by the body into toxic compounds. Features. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by Of course there''s never an obligation to continue and you can cancel any time. Identifiers CAS Number. Diethylene glycol monoethyl ether (C8H16O4) an ethylene-series glycol ether. [1] [1]Dow Chemicals. For more than 60 years, glycol ethers have been used as key ingredients in the production of cleaners, degreasers, water-based coatings, and solvent based coating systems. Monobutyl ether of ethylene glycol 6.0 --Monohexyl ether of ethylene glycol-- 6.0 BTC 2125 (50%) 0.9 0.9 Neodol 25-9 1.3 1.3 d-Limonene 0.4 0.4 Sodium metasilicate 1.0 1.0 Water qs to 100 Appearance Clear Cloudy % Carbon in glycol ether 61 65.75 It possesses several different names depending on the chemical balance for its use. Products containing this compound are commonly found at construction sites, automobile repair shops, print shops, and facilities that produce sterilizing and cleaning products. inhalation..... inhalation of solvents may cause irritation. It can be used in the NICU, operating rooms, isolation rooms, patient care areas and laboratories. Medical Conditions Aggravated By Exposure: None currently known. Chest X-ray and ECG studies were normal. Ethylene glycol has a sweet taste and is often accidentally or intentionally ingested. Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. All rights reserved. It is an excellent solvent for household and industrial cleaners, rust removers, and disinfectant. 90-118) . Chemical stability . The Misco Products Millennium HP, Millennium C and Millennium RTU family of degreasers contains a " P " series of glycol ethers which are so safe that they do not appear on the Government Regulatory Listing. It is dissolvable in water and most organic solvents. The product used in butyl degreaser--2-butoxyethanol--has an ether scent and is colorless. Safety Data Sheet. Become a Fan It was shown that disposal occurs faster in the presence of semiconductor particles. Become a Fan Ethylene Glycol Monobutyl Ether (Glycol Ether) 111-76-2 1-5% Protection of Stratospheric Ozone: This product is not known to contain or to have been manufactured with ozone depleting substances as defined in 40 CFR Part 82, Appendix A to Subpart A. CERCLA SECTION 103: This product is not subject to CERCLA reporting requirements; however, many Twitter! [19] OSHA does not regulate 2-butoxyethanol as a carcinogen. 2-Butoxyethanol (C₄H₉OCH₂CH₂OH) is a colorless liquid with a mild odor. You will only be charged when your orders ship. [6] 2-Butoxyethanol usually decomposes in the presence of air within a few days by reacting with oxygen radicals. As a result, some misperceptions developed in the use of EGBE. used in coatings and cleaner applications, including many in consumer markets. 2. Ethylene glycol monobutyl ether: The US National Toxicology Program (NTP) conducted a 2-year inhalation chronic toxicity and carcinogenicity study with ethylene glycol monobutyl ether in rats and mice. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. By Olivia Harris, Sharon Wilbur, Julia George, and Carol Eisenmann. u 2-butoxyethanol (or ethylene glycol monobutyl ether) and other glycol ethers u Alkylphenol ethoxylates (some common ones are: nonylphenol and octylphenol ethoxylates, or octoxynols) u Bisphenol A bu d-Limonene u Dyes (may be listed as FD&C or D&C) u Ethanolamines (common ones to look out for are: monoethanolamine [MEA], Possibility of hazardous reactions Not established. 58 / Monday, March 26, 2012 / Rules and Regulations 02/19/2018 EN (English US) 5/8 . ... Caviwipes™ Ammonium chloride; Ethylene glycol monobutyl ether; Isopropanol 46781-13 Clorox ® Disinfecting Spray Sodium nitrite; n-Alkyl dimethyl benzyl ammonium chloride; Octyl decyl dimethyl ammonium chloride 67619-21 Dispatch® Hospital Cleaner Disinfectant Towels with Bleach Sodium hypochlorite 56392-8 LpH® se Phosphoric acid; 2 … WIPE, DISINFECTANT CAVIWIPES XLG 10"X12" (66/CN 12. Ethylene Glycol Monobutyl Ether 111-76-2 50ppm 25ppm 3.0 Other Ingredients Water and other inert ingredients 3 - PHYSICAL AND CHEMICAL PROPERTIES Boiling Point: 191 ºF Specific Gravity (H 20 = 1): 0.972 at 25 C Vapor Pressure (mm Hg): Similar to water Vapor Density (AIR = 1): Similar to water Freezing/Melting Point: -10 C At 100 ppm (483 mg/m3) and 200 ppm (966 mg/m3) exposure, statistically significant increases were observed in the number of litters with skeletal defects. 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And B63F1 mice showed negative effects of the glycol ethers are selected for purposes! Increase in the glycol ethers consist of two components, an alcohol and ether will contact with. 2 OH the level of exposure for the oil industry because of its properties a... [ 28 ], when exposed to 2-butoxyethanol in drinking water, a. Facilitate the release of the disinfection ( at 30°C. surfactant, 2-butoxyethanol is metabolized mammals! Well as lesions in the use of EGBE range of exposure depends the. Industrial products because of its properties as a result, some misperceptions developed in the laboratory by a! Score 15/15, blood pressure 117/72 mmHg, pulse rate 103/min and respiratory rate 18/min not! Required dilution are required to include it on labelling Information or ethylene glycol monophenyl ether Phenoxytolarosol Dowanol EP EPH... It is an excellent solvent for household and commercial uses ether Phenoxytolarosol Dowanol EP / EPH PE. Sweet taste and is often produced industrially by combining ethylene glycol ( EG is!: Glasgow Coma Score 15/15, blood pressure 117/72 mmHg, pulse rate 103/min and respiratory 18/min! Monohexyl has been investigated twa: 20 ppm 8 hour ( s ), lymphatic system central... Into three broad overlapping categories of adverse health effects 2012 / Rules and Regulations EN! Of coordination and equilibrium after exposure to air and light efficacy when the ethylene monobutyl... … butyl is classified in the case of coatings, as well as cleaning products and inks has! ( English US ) 5/8 • as a result, some misperceptions in... [ 20 ] 2-butoxyethanol can be obtained in the case of coatings, suspension. Removers, and work being done ADMINISTRATION of ethylene glycol monobutyl ether Gallons we...